The identities of those killed in the fire have not been released and the cause of the fire remains known.
The health conditions of five wounded are reported to be serious after being taken to a hospital in nearby Mexicali, which sits across the border from Calexico, California.
Mayor Jaime Diaz Ochoa said 12 fire extinguishers and eight smoke detectors had been found at the home and that the nonprofit facility in a rural area about a half-hour drive from Mexicali had not been overcrowded.